2-Amino-5-bromo-4-methylpyridine → HCID 57718241, compound

Participants

Reaction Steps

Prepared from 2-amino-5-bromo-4-methylpyridine and 4-(N -piperidinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2-chloro-4-trifluoromethylphenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 13.39 (1 H, br s, NH), 8.39 (1 H, s, A-ring CH ortho to Cl), 8.31 (1 H, d, J 11 Hz, A-ring CH ortho to SO2NH), 7.67 & 7.18 (2×1 H, 2×s, pyridyl CH's), 7.61 (1 H, d, J 11 Hz, A-ring CH ortho to CF3), 7.53 & 7.04 (2×2 H, 2×d, 2×J 10 Hz, Ar CH's of C-ring), 2.91-2.82 (4H, m, CH2NCH2), 2.22 (3H, s, CH3), 1.62-1.46 (4 H, m, CH2CH2CH2CH2CH2), 1.39-1.28 (2 H, m, CH2CH2CH2CH2CH2). Hplc (Luna 2, Gradient 5): rt=6.47 minutes. LC/MS rt=7.13 minutes, 606 (MH+).

Provenance & Evidence