反应详情

Prepared from 2-amino-5-bromo-6-methylpyridine and 4-(N -piperidinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichlorophenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 8.24, 7.76, 7.72, 7.51, 7.19, 7.05 (1 H, 1 H, 2 H, 1 H, 1 H, 2 H, 1 H, 7×d, J 9, 11, 9, 11, 10, 9 Hz, Ar CH's), 7.63 (1 H, s, A-ring CH ortho to 2×Cl), 3.10-3.01 (4H, m, CH2NCH2), 2.58 (3H, s, CH3), 1.76-1.68 (4 H, m, CH2CH2CH2CH2CH2), 1.58-1.47 (2 H, m, CH2CH2CH2CH2CH2). Hplc (Luna 2, Gradient 5): rt=6.40 minutes. LC/MS rt=7.11 minutes, 572/574 (MH+).

1. customrt=6.40 minutes
2. customLC/MS rt=7.11 minutes, 572/574 (MH+)