2-Pyridinamine, 5-bromo-6-methyl- → HCID 57718204, compound

Participants

Reaction Steps

Prepared from 2-amino-5-bromo-6-methylpyridine and 4-(N -piperidinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2-chloro-4-trifluoromethylphenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 8.21 (1 H, d, J 10 Hz, Ar CH ortho to SO2NH), 7.61-7.45 (5 H, m, Ar CH's), 6.96 (2 H, d, J 9 Hz, Ar CH's), 6.76 (1 H, d, J 11 Hz, Ar CH), 2.86-2.78 (4H, m, CH2NCH2), 2.34 (3H, s, CH3), 1.53-1.41 (4 H, m, CH2CH2CH2CH2CH2), 1.33-1.20 (2 H, m, CH2CH2CH2CH2CH2). Hplc (Luna 2, Gradient 5): rt=6.47 minutes. LC/MS rt=7.04 minutes, 606 (MH+).

Provenance & Evidence