2-Amino-5-bromopyridine → HCID 57718234, compound

Participants

Reaction Steps

Prepared from 2-amino-5-bromopyridine and 4-(N -piperidinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichloro-5-methylphenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 8.35 & 8.02 (2×1 H, 2×s, A-ring CH's), 7.63, 7.42 & 7.18 (3×1 H, d, s & d, J 10 Hz, B-ring CH's) 7.55 & 7.11 (2×2 H, 2×d, 2×J 10 Hz, Ar CH's of C-ring), 2.93-2.81 (4H, m, CH2NCH2), 2.34 (3H, s, CH3), 1.60-1.48 (4 H, m, CH2CH2CH2CH2CH2), 1.39-1.27 (2 H, m, CH2CH2CH2CH2CH2). Hplc (Luna 2, Gradient 5): rt=6.77 minutes. LC/MS rt=7.44 minutes, 572/574 (MH+).

Provenance & Evidence