2-Amino-5-bromopyridine → HCID 57718225, compound

Participants

Reaction Steps

Prepared from 2-amino-5-bromopyridine and 4-(N -piperidinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichlorophenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 11.95 (1 H, br s, NH), 8.55 (1 H, s, Ar CH ortho to 2×Cl), 8.29 (1 H, d, CH ortho to SO2NH), 7.85, 7.61, 7.54 & 7.39 (4×1 H, d, s, d & d, J 11, 10 & 11 Hz, A- & B-ring CH's) 7.73 & 7.30 (2×2 H, 2×d, 2×J 10 Hz, Ar CH's of C-ring), 3.10-3.01 (4H, m, CH2NCH2), 2.18 (3H, s, CH3), 1.79-1.68 (4 H, m, CH2CH2CH2CH2CH2), 1.60-1.48 (2 H, m, CH2CH2CH2CH2CH2). Hplc (Luna 2, Gradient 5): rt=6.48 minutes. LC/MS rt=7.19 minutes, 558/560 (MH+).

Provenance & Evidence