反应详情

Prepared from 2-amino-5-bromo-6-methylpyridine and 4-(N-morpholinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichlorophenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 8.09 (1 H, d, J 10 Hz, A-ring CH ortho to SO2NH), 7.68, 7.35 & 7.12 (3×1 H, 3×d, 3×J 10 Hz, pyridyl CH's & A-ring CH ortho to Cl), 7.58 & 7.08 (2×2 H, 2×d, 2×J 10 Hz, C-ring CH's), 7.46 (1 H, s, A ring CH ortho to 2×Cl), 3.71-3.62 (4H, m, CH2OCH2), 2.94-2.85 (4H, m, CH2NCH2), 2.49 (3H, s, CH1). Hplc (Luna 2, Gradient 5): rt=5.81 minutes. LC/MS rt=6.58 minutes, 574/576 (MH+).

1. customrt=5.81 minutes
2. customLC/MS rt=6.58 minutes, 574/576 (MH+)