反应详情

Prepared from 2-amino-5-bromo-6-methylpyridine and 4-(N -morpholinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2-chloro-4-trifluoromethylphenylsulfonyl chloride according to General Method 11 step 1. 1H NMR (CDCl3): 8.24 (1 H, d, J 10 Hz, Ar CH ortho to SO2NH), 7.65 (1 H, s, A-ring CH ortho to Cl & CF3), 7.61-7.48 (4 H, m, Ar CH's), 7.03 (2 H, d, J 9 Hz, Ar CH's), 6.81 (1 H, d, J 11 Hz, Ar CH), 3.66-3.58 (4H, m, CH2OCH2), 2.90-2.81 (4H, m, CH2NCH2), 2.41 (3H, s, CH3). Hplc (Luna 2, Gradient 5): rt=5.94 minutes. LC/MS rt=6.60 minutes, 608 (MH+).

1. customrt=5.94 minutes
2. customLC/MS rt=6.60 minutes, 608 (MH+)