Benzenesulfonyl chloride, 2,4-dichloro- → 2,4-Dichloro-N-{5-[4-(morpholine-4-sulfonyl)-phenylsulfanyl]-6-trifluoromethyl-pyridin-2-yl}-benzenesulfonamide

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Reaction Steps

Prepared from 2-amino-5-bromo-6-trifluoromethylpyridine and 4-(N -morpholinylsulfonyl)thiophenol according to General Method 11 step 1 followed by reaction with 2,4-dichlorophenylsulfonyl chloride according to General Method 11 step 2. 1H NMR (CDCl3): 8.10 (1 H, d, J 10 Hz, A-ring CH ortho to SO2NH), 7.62 & 7.35 (2×1 H, 2×d, 2×J 10 Hz, pyridyl CH's), 7.56 & 7.18 (2×2 H, 2×d, 2×J 10 Hz, C-ring CH's), 7.45 (1 H, s, A ring CH ortho to 2×Cl), 7.20 (1 H, d, J 10 Hz, A-ring CH ortho to Cl), 3.71-3.63 (4H, m, CH2OCH2), 2.93-2.85 (4H, m, CH2NCH2). Hplc (Luna 2, Gradient 5): rt=6.39 minutes. LC/MS rt=7.06 minutes, 628/630 (MH+).

Provenance & Evidence