Benzenesulfonyl chloride, 2,4-dichloro- → HCID 57718221, compound

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Reaction Steps

A solution of the 2-amino-5-[4-(piperidine-1-sulfonyl) -phenylsulfanyl]-isonicotinic acid pentyl ester (500 mg, 1.1 μmol), 2,4-dichlorobenzenesulfonylchloride (327 mg, 1.33 mmol) and 4-dimethylaminopyridine (134 mg, 1.1 mmol) in pyridine (10 ml) was stirred at 40° C. overnight. The pyridine was removed under reduced pressure and the residue purified by flash column chromatography using ethyl acetate 1/2 hexane as eluent to afford 2-(2,4-dichloro-benzenesulfonylamino)-5-[4-(piperidine-1-sulfonyl)-phenylsulfanyl]-isonicotinic acid pentyl ester as a yellow foam (217 mg, 29%).

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