2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride → HCID 57718182, compound

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5-Methyl-6-[4-(piperidine-1-sulfonyl)-phenylsulfanyl]-pyridazin-3-ylamine (110 mgs), 2-chloro-4-trifluoromethylbenzenesulfonyl chloride (160 mgs) and pyridine (1 ml) were heated at 50° C. under nitrogen for 72 hours. All volatiles were removed and the residue purified by Preparative HPLC to give 2-chloro-N-{5-methyl-6-[4-(piperidine-1-sulfonyl)-phenylsulfanyl]-pyridazin-3-yl}-4-trifluoromethyl-benzenesulfonamide 20 mg. 1H NMR (CDCl3) 8.25 (1H, d) 7.75 (2H, m) 7.7 (1H, s) 7.6 (3H, m) 6.95 (1H, s) 3.0 (4H, m) 2.3 (3H, s) 1.6 (4H, m) 1.45 (2H, m). LCMS Polarity/Scan type: Negative Q1 Scan. M.wt. 605 (—H), 607 (—H). Retention time 7.05 minutes. HPLC:—MS8. Retention time 4.99 minutes.

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