HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 1-Benzyl-2-(bromomethyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | (1-Benzylpiperidin-2-yl)methanol | HCID 2735486 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl-2-(bromomethyl)piperidine | HCID 23146274 | 39.8% |
Reaction Steps
(RS)-(1-Benzyl-piperidin-2-yl)-methanol (R. Sreekumar et al, Tetrahedron Lett., 1998, 39 5151) (10.0 g) was converted to the title compound (5.2 g) by treatment with triphenylphosphine (13.0 g) and N-bromosuccinimide (9.4 g) in dichloromethane using literature procedures, (Tetrahedron Lett, 1999, 40, 7477-8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893090B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-50ca480cb712474b9583732e4783611c |
| Source note | uspto-grants-2011_02 |