HRID1367050

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(S(=O)(=O)[O-])c(C)cc1N=Nc1c(O)ccc2cc(S(=O)(=O)[O-])ccc12.[Na+].[Na+]

HCID33258

Allura Red C.I.16035

C18H14N2Na2O8S2

结构：Cc1nc(C(=O)N2CCCCC2Cc2cc3cc(Br)ccc3o2)c(-c2ccc(F)cc2)s1

HCID23146280

未命名化合物

HCID178418546

未命名化合物

PRODUCTS

生成物

结构：Cc1nc(C(=O)N2CCCCC2Cc2cc3cc(C#N)ccc3o2)c(-c2ccc(F)cc2)s1

HCID23146247

未命名化合物

PROCEDURE

实验过程

The title compound (19 mg) was prepared from (RS)-1-[2-(5-bromo-benzofuran-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone, E129 (420 mg) and copper(I) cyanide according to a procedure similar to that described for Example 67.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d40d52c8fbf845d29debe102123e7034
来源数据集: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07893090B2
来源说明: uspto-grants-2011_02

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][N:12]3[C:17]([C:19]3[N:20]=[C:21]([CH3:31])[S:22][C:23]=3[C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)=[O:18])=[CH:7][C:6]=2[CH:32]=1.CC1C(S([O-])(=O)=O)=CC(OC)=[C:36]([N:46]=NC2C(O)=CC=C3C=2C=CC(S([O-])(=O)=O)=C3)C=1.[Na+].[Na+].[Cu]C#N>>[C:36]([C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][N:12]3[C:17]([C:19]3[N:20]=[C:21]([CH3:31])[S:22][C:23]=3[C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)=[O:18])=[CH:7][C:6]=2[CH:32]=1)#[N:46]