2-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chloride → HCID 23146248, compound

HRID 1367051Notes

Reaction equation

HRID 1367051 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([CH3:13])=[N:10][C:9]=2[C:14](Cl)=[O:15])=[CH:4][CH:3]=1.[Br:17][C:18]1[C:23]2[CH:24]=[C:25]([CH2:27][CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]3)[O:26][C:22]=2[CH:21]=[CH:20][CH:19]=1>>[Br:17][C:18]1[C:23]2[CH:24]=[C:25]([CH2:27][CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][N:29]3[C:14]([C:9]3[N:10]=[C:11]([CH3:13])[S:12][C:8]=3[C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[O:15])[O:26][C:22]=2[CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 223241192-Methyl-5-(4-fluorophenyl)thiazole-4-carbonyl chlorideHCID 23146342HCID 23146342, compound

Product 1

HCID 23146248HCID 23146248, compound

Procedure

The title compound (0.45 g) was prepared from 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carbonyl chloride (0.89 g) and 2-(4-bromo-benzofuran-2-ylmethyl)-piperidine, D72 (0.88 g) by a procedure similar to that described for Example 1.

Sources & evidence

ORD record
ord-89e81feab2044853995a9d280efc2078
Source dataset
uspto-grants-2011_02
Patent number
US07893090B2

Reaction notes

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