5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid → HCID 23146308, compound

HRID 1367053Notes

Reaction equation

HRID 1367053 reaction equation
[CH3:1][C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][NH:13]1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[S:29][C:28]([CH3:30])=[N:27][C:26]=2[C:31](O)=[O:32])=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[S:29][C:28]([CH3:30])=[N:27][C:26]=2[C:31]([N:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH:12]2[CH2:11][C:3]2[O:4][C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[C:2]=2[CH3:1])=[O:32])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 223241255-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylic acidHCID 23146258HCID 23146258, compound

Product 1

HCID 23146308HCID 23146308, compound

Procedure

The title compound (18 mg) was prepared from (RS)-2-(3-methyl-benzofuran-2-ylmethyl)-piperidine, D74 (92 mg) and 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid (190 mg) according to a procedure similar to that described for Example 4.

Sources & evidence

ORD record
ord-f36a8d762635456bb8d7049ac993eed7
Source dataset
uspto-grants-2011_02
Patent number
US07893090B2

Reaction notes

Loading…