HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(6-Bromo-2,3,4-trifluorophenyl)-3,3-dimethylpiperidin-2-one → 3,3-Dimethyl-6-(2,3,4-trifluorophenyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(6-Bromo-2,3,4-trifluorophenyl)-3,3-dimethylpiperidin-2-one | HCID 86616392 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,3-Dimethyl-6-(2,3,4-trifluorophenyl)piperidin-2-one | HCID 66973282 | — |
Reaction Steps
A solution of 6-(6-bromo-2,3,4-trifluorophenyl)-3,3-dimethylpiperidin-2-one (27.0 mg, 0.080 mmol, described in Intermediate 17) and 10% palladium on carbon in degassed EtOH (2 mL) was stirred under a hydrogen balloon for 3 h. The reaction mixture was filtered through a Celite pad and concentrated in vacuo to provide the title compound. MS: m/z=258 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893079B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-461d772ca286446895a7d63c009c341d |
| Source note | uspto-grants-2011_02 |