HCID 66865136, compound → HCID 57974031, compound

HRID 1367193Notes

Reaction equation

HRID 1367193 reaction equation
FC1C=C([C@@H]2CCCC(=O)N2[C:16]([O:18]C(C)(C)C)=[O:17])C=C(F)C=1.[F:23][C:24]1[CH:25]=[C:26]([C@H:31]2[N:36]([C:37](OC(C)(C)C)=O)[C:35](=[O:44])[C@H:34]([CH3:45])[CH2:33][CH2:32]2)[CH:27]=[C:28]([F:30])[CH:29]=1>>[F:30][C:28]1[CH:27]=[C:26]([C@H:31]2[N:36]([CH2:37][C:16]([OH:18])=[O:17])[C:35](=[O:44])[C@H:34]([CH3:45])[CH2:33][CH2:32]2)[CH:25]=[C:24]([F:23])[CH:29]=1

Participants

3

Reactant 2

HCID 66865136HCID 66865136, compoundHCID 66973304HCID 66973304, compound

Product 1

HCID 57974031HCID 57974031, compound

Procedure

Essentially following the procedures described for Intermediate 26, but using tert-butyl (3R,6S)-6-(3,5-difluorophenyl)-3-methylpiperidin-2-one-1-carboxylate in place of tert-butyl (6S)-6-(3,5-difluorophenyl)-3,3-diethylpiperidin-2-one-1-carboxylate, the title compound was prepared. MS: m/z=284 (M+1).

Sources & evidence

ORD record
ord-82c47adc484144c8b35da2080eb5c1c1
Source dataset
uspto-grants-2011_02
Patent number
US07893079B2

Reaction notes

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