Methanol → 4-Methoxy-1H-pyrrolo[2,3-b]pyridine

HRID 1367279Notes

Reaction equation

HRID 1367279 reaction equation
Cl[C:2]1[CH:10]=[CH:9][N:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2.[OH-:11].[Na+].[CH3:13]O>>[CH3:13][O:11][C:2]1[CH:10]=[CH:9][N:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2

Participants

4

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 112405674-Methoxy-1H-pyrrolo[2,3-b]pyridine

Procedure

4-methoxy-7-azaindole 20 was prepared by reacting 4-chloro-7-azaindole 24 (prepared as described in Example 9) with sodium hydroxide in methanol as described by Girgis, N. et.al., J. Heterocyclic. Chem. 1989, 26:317-325.

Sources & evidence

ORD record
ord-dc18b7b764d643889a20c35361603542
Source dataset
uspto-grants-2011_02
Patent number
US07893075B2

Reaction notes

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