Sodium Thiosulfate → (5-Bromo-6-fluoro-pyridin-2-yl)-(4-chloro-benzyl)-amine

Participants

Reaction Steps

To (4-chloro-benzyl)-(6-fluoro-pyridin-2-yl)-amine (536, 1.03 g, 4.35 mmol) in acetonitrile (30.0 mL), under an atmosphere of nitrogen, N-bromosuccinimide (0.820 g, 4.61 mol) was added slowly. After 2 hours, the reaction was poured into a solution of sodium thiosulfate and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, concentrated and crystallized with ethyl acetate and hexane to give a white solid (5.37, 1.10 g, 80.1%).

Provenance & Evidence