[5-(3-chloro-benzylamino)-2-methyl-2H-pyrazol-3-yl]-methanol → 5-(3-chloro-benzylamino)-2-methyl-2H-pyrazole-3-carbaldehyde

Participants

Reaction Steps

[5-(3-Chloro-benzylamino)-2-methyl-2H-pyrazol-3-yl]-methanol (647, 0.821 g, 3.26 mmol) was combined with dichloromethane (70 mL) and manganese(IV) oxide (4 g). The reaction was stirred at room temperature overnight under an atmosphere of nitrogen. The mixture was filtered through Celite and concentrated. Purification by silica gel column chromatography eluting with a gradient of ethyl acetate (10-100%) in hexane gave the desired aldehyde (648, 0.482 g, 60%).

Provenance & Evidence