Thiophenol → HCID 66918764, compound

Participants

Reaction Steps

The reaction of the mixture of (1R,2R,4R) and (1R,2R,4S)-2-(1-cyano-cyclopropylcarbamoyl)-4-methanesulfonyloxy-cyclopentanecarboxylic acid ethyl ester from step 3 with thiophenol performed in analogy to example 1, step 5, yielded a crude material which was purified on silica using n-heptane/EtOAc (3:2) to give in the first fraction the desired (1R,2R,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-phenylsulfanyl-cyclopentanecarboxylic acid ethyl ester as a colorless oil. MS: 359.2 (M+H)+.

Provenance & Evidence