Methanesulfonate → HCID 86649019, compound

HRID 1367467Notes

Reaction equation

[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([OH:11])[CH2:8][C@H:7]1[C:12](=[O:17])[NH:13][CH2:14][C:15]#[N:16])=[O:5])[CH3:2].[S:18]([O-])(=[O:21])(=[O:20])[CH3:19]>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@@H:9]([O:11][S:18]([CH3:19])(=[O:21])=[O:20])[CH2:8][C@H:7]1[C:12](=[O:17])[NH:13][CH2:14][C:15]#[N:16])=[O:5])[CH3:2]

Participants

Reactant 2

HCID 85257Methanesulfonate

HCID 86649018HCID 86649018, compound

Product 1

HCID 86649019HCID 86649019, compound

Procedure

(1R,2R,4S)-2-(Cyanomethyl-carbamoyl)-4-hydroxy-cyclopentanecarboxylic acid ethyl ester (second fraction from step 2) was converted to the corresponding mesylate according to the procedure from example 1, step 4 to give (1R,2R,4S)-2-(cyanomethyl-carbamoyl)-4-methanesulfonyloxy-cyclopentanecarboxylic acid ethyl ester as a colorless solid. MS: 319.3 (M+H)+.

Sources & evidence

ORD record: ord-412766c358fa4d8bbad33f2d652ed66f
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07893099B2

Reaction notes

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