2,6-Dimethylmorpholine, cis- → HCID 49835088, compound

HRID 1367469Notes

Reaction equation

HRID 1367469 reaction equation
[CH3:1][C@H:2]1[O:7][C@@H:6]([CH3:8])[CH2:5][NH:4][CH2:3]1.[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([S:16]([C@H:19]2[CH2:23][C@@H:22]([C:24](O)=[O:25])[C@H:21]([C:27](=[O:32])[NH:28][CH2:29][C:30]#[N:31])[CH2:20]2)(=[O:18])=[O:17])=[C:12]([CH3:33])[CH:11]=1>>[C:30]([CH2:29][NH:28][C:27]([C@@H:21]1[CH2:20][C@@H:19]([S:16]([C:13]2[CH:14]=[CH:15][C:10]([Cl:9])=[CH:11][C:12]=2[CH3:33])(=[O:17])=[O:18])[CH2:23][C@H:22]1[C:24]([N:4]1[CH2:5][C@@H:6]([CH3:8])[O:7][C@@H:2]([CH3:1])[CH2:3]1)=[O:25])=[O:32])#[N:31]

Participants

3

Reactant 2

HCID 6415002,6-Dimethylmorpholine, cis-HCID 87204741HCID 87204741, compound

Product 1

HCID 49835088HCID 49835088, compound

Procedure

The title compound was prepared in analogy to example 11 using cis-2,6-dimethymorpholine instead of 2-oxa-6-aza-spiro[3.3]heptan and (1R,2R,4R)-4-(4-chloro-2-methyl-benzenesulfonyl)-2-(cyanomethyl-carbamoyl)-cyclopentanecarboxylic acid instead of (1R,2R,4R)-4-benzenesulfonyl-2-(1-cyano-cyclopropylcarbamoyl)-cyclopentanecarboxylic acid. Colorless oil. MS: 480.0 (M−H)−.

Sources & evidence

ORD record
ord-9fc3a9f6a5eb4b4dbf600673b6ea8cf4
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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