Hydrochloric Acid → 3-(2-Chloro-benzenesulfonyl)-cyclopentanecarboxylic acid

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Reaction Steps

A solution of 3-(2-chloro-benzenesulfonyl)-cyclopentanecarboxylic acid methyl ester (0.25 g, 1.0 eq) in methanol (8.0 mL) was treated with 1N LiOH (1.6 mL, 2.0 eq). The mixture was stirred at RT for 3 h and then acidified to pH 4 with HCl 1N. The methanol was evaporated and the residue extracted with ethyl acetate. The organic phase was dried over sodium sulfate and evaporated. The title compound was obtained as a colorless oil (0.25 g, 100%) and was used crude. MS (ESI): m/z=287.3 [M−H]−.

Provenance & Evidence