1-Amino-1-cyclopropanecarbonitrile hydrochloride → HCID 66918531, compound

HRID 1367493Notes

Reaction equation

HRID 1367493 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([CH:11]1[CH2:15][C@@H:14]([C:16](O)=[O:17])[C@H:13]([CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[CH2:12]1)(=[O:10])=[O:9].[CH2:28]1[C:30]([NH2:33])([C:31]#[N:32])[CH2:29]1.Cl>>[C:31]([C:30]1([NH:33][C:16]([C@@H:14]2[CH2:15][CH:11]([S:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])(=[O:10])=[O:9])[CH2:12][C@H:13]2[CH2:19][O:20][C:21]2[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=2)=[O:17])[CH2:28][CH2:29]1)#[N:32]

Participants

3

Reactant 2

HCID 145863631-Amino-1-cyclopropanecarbonitrile hydrochlorideHCID 66919040HCID 66919040, compound

Product 1

HCID 66918531HCID 66918531, compound

Procedure

The title compound was synthesized in analogy to Example 68/69, Step 11, from (1R,2R)-4-(2-Chloro-benzenesulfonyl)-2-(4-chloro-phenoxymethyl)-cyclopentanecarboxylic acid (epimeric mixture) and 1-amino-cyclopropyl cyanic hydrochloride to afford the desired product as a yellow oil. MS (EI): 493.2 (M)+.

Sources & evidence

ORD record
ord-8b39a02473dd4217a4ac0ea1ed7de07f
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

Loading…