1-Aminocyclopropanecarbonitrile → HCID 59619335, compound

HRID 1367498Notes

Reaction equation

HRID 1367498 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([CH:12]1[CH2:16][CH2:15][CH:14]([C:17]([OH:19])=O)[CH2:13]1)(=[O:11])=[O:10].[NH2:20][C:21]1([C:24]#[N:25])[CH2:23][CH2:22]1>>[C:24]([C:21]1([NH:20][C:17]([C@@H:14]2[CH2:15][CH2:16][C@@H:12]([S:9]([C:3]3[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=3[Cl:1])(=[O:10])=[O:11])[CH2:13]2)=[O:19])[CH2:23][CH2:22]1)#[N:25]

Participants

3

Reactant 2

HCID 5568881-AminocyclopropanecarbonitrileHCID 66918566HCID 66918566, compound

Product 1

HCID 59619335HCID 59619335, compound

Procedure

The title compound was synthesized in analogy to Example 68/69, Step 11, from rac-(1S,3S)-3-(2-chloro-4-fluoro-benzenesulfonyl)-cyclopentanecarboxylic acid and 1-amino-cyclopropanecarbonitrile to afford the desired product as a light yellow oil. MS (EI): 371.0 (M+H)+.

Sources & evidence

ORD record
ord-e3b3629413e9498aae8318e58bcb4a53
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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