3,3-Difluoropyrrolidine → HCID 49835580, compound

HRID 1367501Notes

Reaction equation

HRID 1367501 reaction equation
[C:1]([C:3]1([NH:6][C:7]([CH:9]2[CH2:13][CH2:12][CH:11]([S:14]([C:17]3[CH:22]=[CH:21][C:20](F)=[CH:19][C:18]=3[Cl:24])(=[O:16])=[O:15])[CH2:10]2)=[O:8])[CH2:5][CH2:4]1)#[N:2].[F:25][C:26]1([F:31])[CH2:30][CH2:29][NH:28][CH2:27]1>>[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][CH2:12][C@@H:11]([S:14]([C:17]3[CH:22]=[CH:21][C:20]([N:28]4[CH2:29][CH2:30][C:26]([F:31])([F:25])[CH2:27]4)=[CH:19][C:18]=3[Cl:24])(=[O:16])=[O:15])[CH2:10]2)=[O:8])[CH2:5][CH2:4]1)#[N:2]

Participants

3

Reactant 2

HCID 27828273,3-DifluoropyrrolidineHCID 72340489HCID 72340489, compound

Product 1

HCID 49835580HCID 49835580, compound

Procedure

The title compound was synthesized in analogy to Example 80, from rac-(1S,35)-3-(2-chloro-4-fluoro-benzenesulfonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide and 3,3-difluoro-pyrrolidine to afford the desired product as a light yellow oil. MS (EI): 458.2 (M+H)+.

Sources & evidence

ORD record
ord-c4ee1a5c9852456291065783dafaf461
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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