3,5-Dimethylisoxazole-4-boronic acid → (1S,2S,4S)-4-[4-(3,5-Dimethyl-isoxazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-2-ethoxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide

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Reaction Steps

The title compound was prepared in analogy to example 62 using 3,5-dimethyl-isoxazole-4-boronic acid instead of 2.4-difluorophenylboronic acid and (1R,2R,4R) and (1S,2S,4S)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-2-ethoxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide instead of (1R,2R,4R) and (1S,2S,4S)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-2-methoxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide. White solid. MS (EI): 526.0 (M+H)+.

Provenance & Evidence