HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-trifluoromethylbenzenethiol → (1R,2R,4S)-2-(3,3-Difluoro-azetidine-1-carbonyl)-4-(4-fluoro-2-trifluoromethyl-phenylsulfanyl)-cyclopentanecarboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-trifluoromethylbenzenethiol | HCID 50998002 | — |
| Reactant | (1R,2R,4R)-2-(3,3-Difluoro-azetidine-1-carbonyl)-4-methanesulfonyloxy-cyclopentanecarboxylic acid ethyl ester | HCID 86649025 | — |
| Product | (1R,2R,4S)-2-(3,3-Difluoro-azetidine-1-carbonyl)-4-(4-fluoro-2-trifluoromethyl-phenylsulfanyl)-cyclopentanecarboxylic acid ethyl ester | HCID 86649027 | — |
Reaction Steps
The title compound was prepared in analogy to Example 68/69, step 8, using (1R,2R,4R)-2-(3,3-Difluoro-azetidine-1-carbonyl)-4-methanesulfonyloxy-cyclopentanecarboxylic acid ethyl ester (Example 117, step 3) and 4-fluoro-2-trifluoromethyl-benzenethiol (Intermediate 2). Light yellow oil. MS (EI): 456.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893099B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-e78a9c6a290c43098eae362f172cadd0 |
| Source note | uspto-grants-2011_02 |