1-Amino-1-cyclopropanecarbonitrile hydrochloride → HCID 59619447, compound

HRID 1367517Notes

Reaction equation

HRID 1367517 reaction equation
[F:1][C:2]1([F:30])[CH2:5][N:4]([C:6]([C@@H:8]2[CH2:12][C@H:11]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[C:23]([F:26])([F:25])[F:24])(=[O:15])=[O:14])[CH2:10][C@H:9]2[C:27]([OH:29])=O)=[O:7])[CH2:3]1.[CH2:31]1[C:33]([NH2:36])([C:34]#[N:35])[CH2:32]1.Cl>>[C:34]([C:33]1([NH:36][C:27]([C@@H:9]2[CH2:10][C@@H:11]([S:13]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[C:23]([F:24])([F:26])[F:25])(=[O:15])=[O:14])[CH2:12][C@H:8]2[C:6]([N:4]2[CH2:5][C:2]([F:30])([F:1])[CH2:3]2)=[O:7])=[O:29])[CH2:31][CH2:32]1)#[N:35]

Participants

3

Reactant 2

HCID 145863631-Amino-1-cyclopropanecarbonitrile hydrochlorideHCID 87204759HCID 87204759, compound

Product 1

HCID 59619447HCID 59619447, compound

Procedure

The title compound was prepared in analogy to Example 117, step 7, using (1R,2R,4S)-2-(3,3-Difluoro-azetidine-1-carbonyl)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-cyclopentanecarboxylic acid and 1-amino-cyclopropyl cyanic hydrochloride. White solid. MS (EI): 524.1 (M+H)+.

Sources & evidence

ORD record
ord-e967d9574cf142a19329089990b64efe
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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