2-Methylpyridine-4-boronic acid → HCID 59619411, compound

HRID 1367520Notes

Reaction equation

HRID 1367520 reaction equation
[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20](Br)=[CH:19][C:18]=3[C:24]([F:27])([F:26])[F:25])(=[O:16])=[O:15])[CH2:11][C@H:10]2[C:28]([N:30]2[CH2:33][C:32]([F:35])([F:34])[CH2:31]2)=[O:29])=[O:8])[CH2:5][CH2:4]1)#[N:2].[N:36]1[CH:41]=[CH:40][C:39](B(O)O)=[CH:38][C:37]=1[CH3:45]>>[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20]([C:39]4[CH:40]=[CH:41][N:36]=[C:37]([CH3:45])[CH:38]=4)=[CH:19][C:18]=3[C:24]([F:27])([F:26])[F:25])(=[O:16])=[O:15])[CH2:11][C@H:10]2[C:28]([N:30]2[CH2:33][C:32]([F:35])([F:34])[CH2:31]2)=[O:29])=[O:8])[CH2:5][CH2:4]1)#[N:2]

Participants

3

Reactant 2

HCID 41926642-Methylpyridine-4-boronic acidHCID 59619453HCID 59619453, compound

Product 1

HCID 59619411HCID 59619411, compound

Procedure

The title compound was prepared in analogy to Example 120 using (1R,2R,4R)-4-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (Example 117) and 2-picoline-4-boronic acid. Yellow solid. MS (EI): 597.1 (M+H)+.

Sources & evidence

ORD record
ord-4058c0ce0fc84169927485f2d87d3273
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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