1-Cyclopropylpiperazine dihydrochloride → HCID 59619249, compound

HRID 1367526Notes

Reaction equation

HRID 1367526 reaction equation
[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20](F)=[CH:19][C:18]=3[C:24]([F:27])([F:26])[F:25])(=[O:16])=[O:15])[CH2:11][C@H:10]2[C:28]([N:30]2[CH2:33][C:32]([F:35])([F:34])[CH2:31]2)=[O:29])=[O:8])[CH2:5][CH2:4]1)#[N:2].Cl.Cl.[CH:38]1([N:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[CH2:40][CH2:39]1>>[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20]([N:44]4[CH2:45][CH2:46][N:41]([CH:38]5[CH2:40][CH2:39]5)[CH2:42][CH2:43]4)=[CH:19][C:18]=3[C:24]([F:25])([F:26])[F:27])(=[O:15])=[O:16])[CH2:11][C@H:10]2[C:28]([N:30]2[CH2:31][C:32]([F:35])([F:34])[CH2:33]2)=[O:29])=[O:8])[CH2:4][CH2:5]1)#[N:2]

Participants

3

Reactant 2

HCID 212208121-Cyclopropylpiperazine dihydrochlorideHCID 59619447HCID 59619447, compound

Product 1

HCID 59619249HCID 59619249, compound

Procedure

The title compound was prepared in analogy to Example 127 using (1R,2R,4R)-2-(3,3-Difluoro-azetidine-1-carbonyl)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (Example 118) and 1-cyclopropylpiperazine-bis-hydrochloric acid. White solid. MS (EI): 630.2 (M+H)+.

Sources & evidence

ORD record
ord-9f10f8af16434349927e73cea22acf10
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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