1-Tert-butylpiperazine → HCID 59619440, compound

HRID 1367527Notes

Reaction equation

HRID 1367527 reaction equation
[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20](F)=[CH:19][C:18]=3[C:24]([F:27])([F:26])[F:25])(=[O:16])=[O:15])[CH2:11][C@H:10]2[C:28]([N:30]2[CH2:33][C:32]([F:35])([F:34])[CH2:31]2)=[O:29])=[O:8])[CH2:5][CH2:4]1)#[N:2].[C:36]([N:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1)([CH3:39])([CH3:38])[CH3:37]>>[C:1]([C:3]1([NH:6][C:7]([C@@H:9]2[CH2:13][C@@H:12]([S:14]([C:17]3[CH:22]=[CH:21][C:20]([N:43]4[CH2:44][CH2:45][N:40]([C:36]([CH3:39])([CH3:38])[CH3:37])[CH2:41][CH2:42]4)=[CH:19][C:18]=3[C:24]([F:27])([F:26])[F:25])(=[O:16])=[O:15])[CH2:11][C@H:10]2[C:28]([N:30]2[CH2:31][C:32]([F:35])([F:34])[CH2:33]2)=[O:29])=[O:8])[CH2:4][CH2:5]1)#[N:2]

Participants

3

Reactant 2

HCID 35305721-Tert-butylpiperazineHCID 59619447HCID 59619447, compound

Product 1

HCID 59619440HCID 59619440, compound

Procedure

The title compound was prepared in analogy to Example 127 using (1R,2R,4R)-2-(3,3-Difluoro-azetidine-1-carbonyl)-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (Example 118) and 1-tert-butyl-piperazine. Light yellow foam. MS (EI): 646.2 (M+H)+.

Sources & evidence

ORD record
ord-4f7c231f86ca43cb8718b9c4487fa620
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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