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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1367531생성일: 2026년 10월 25일

(2S)-1,1,1-Trifluoropropan-2-ol → (1R,2R,4R)-4-[2-Chloro-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzenesulfonyl]-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide

https://huagongshe.com/reaction/1367531

반응식

참여 물질

역할이름HCID투입량
반응물(2S)-1,1,1-Trifluoropropan-2-olHCID 6999971—
반응물(1R,2R,4R)-4-(2-Chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amideHCID 59619273—
생성물(1R,2R,4R)-4-[2-Chloro-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzenesulfonyl]-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amideHCID 59619227—

반응 단계

The title compound was prepared in analogy to Example 134 using (1R,2R,4R)-4-(2-Chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amid (Example 119) and (S)-1,1,1-trifluoro-propan-2-ol. Off-white solid. MS (EI): 584.1 (M+H)+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07893099B2
출처 데이터셋uspto-grants-2011_02
ORD IDord-a01aaacb8a06418fa231f53223fae963
출처 메모uspto-grants-2011_02