2-Chloro-4-fluorothiophenol → HCID 66919051, compound

HRID 1367538Notes

Reaction equation

HRID 1367538 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][CH:9](OS(C)(=O)=O)[CH2:8][C@H:7]1[CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)=[O:5])[CH3:2].[Cl:25][C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=1[SH:33]>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][CH:9]([S:33][C:27]2[CH:28]=[CH:29][C:30]([F:32])=[CH:31][C:26]=2[Cl:25])[CH2:8][C@H:7]1[CH2:16][O:17][C:18]1[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 5194462-Chloro-4-fluorothiophenolHCID 86649028HCID 86649028, compound

Product 1

HCID 66919051HCID 66919051, compound

Procedure

The title compound was prepared in analogy to example 68 step 8 using (1R,2R)-2-(4-Fluoro-phenoxymethyl)-4-methanesulfonyloxy-cyclopentanecarboxylic acid ethyl ester (epimeric mixture, example 143 and 144 step 3) and 2-chloro-4-fluorothiophenol. Yellow oil (56%). MS (EI): 378.3 (M+NH4)+.

Sources & evidence

ORD record
ord-b2f6074d5ffa42dd9743ebce6d2349b5
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

Loading…