2-Chloro-4-fluorothiophenol → HCID 66918666, compound

HRID 1367550Notes

Reaction equation

HRID 1367550 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9](OS(C)(=O)=O)[CH2:8][C@H:7]1[CH2:16][O:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)=[O:5])[CH3:2].[Cl:27][C:28]1[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:29]=1[SH:35]>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@@H:9]([S:35][C:29]2[CH:30]=[CH:31][C:32]([F:34])=[CH:33][C:28]=2[Cl:27])[CH2:8][C@H:7]1[CH2:16][O:17][CH2:18][C:19]1[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 5194462-Chloro-4-fluorothiophenolHCID 86649033HCID 86649033, compound

Product 1

HCID 66918666HCID 66918666, compound

Procedure

The title compound was prepared in analogy to example 68 step 8 using (1R,2R,4R)-4-methanesulfonyloxy-2-(4-methoxy-benzyloxymethyl)-cyclopentanecarboxylic acid ethyl ester (example 153 step 6) and 2-chloro-4-fluorothiophenol. Yellow oil (95%). MS (EI): 452 (M)−.

Sources & evidence

ORD record
ord-6114cdeab79b4dc294fb850cd4e804a4
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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