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HRID 1367555作成日：2026年10月25日

1-Cyclopropylpiperazine → (1R,2R,4R)-4-[2-Chloro-4-(4-cyclopropyl-piperazin-1-yl)-benzenesulfonyl]-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide

https://huagongshe.com/reaction/1367555

反応式

関与物質

役割名称HCID仕込み量
反応物1-CyclopropylpiperazineHCID 4742004—
反応物(1R,2R,4R)-4-(2-Chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amideHCID 59619273—
生成物(1R,2R,4R)-4-[2-Chloro-4-(4-cyclopropyl-piperazin-1-yl)-benzenesulfonyl]-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amideHCID 59619374—

反応手順

The title compound was prepared in analogy to example 127 using (1R,2R,4R)-4-(2-chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-azetidine-1-carbonyl)-cyclopentanecarboxylic acid-(1-cyano-cyclopropyl)-amide (example 119 step 4) and N-cyclopropylpiperazine bis hydrobromic salt (CAS # 159974-58-0). White solid (64%). MS (EI): 596.2 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07893099B2
出典データセットuspto-grants-2011_02
ORD IDord-dba72640a6e84a6f9e084df8c689bb45
出典メモuspto-grants-2011_02