Water → HCID 66918907, compound

Participants

Reaction Steps

A mixture of (1S,2R,4R) and (1R,2S,4S)-4-(4-bromo-2-trifluoromethyl-phenylsulfanyl)-2-(tetrahydro-pyran-4-yloxy)-cyclopentanecarbonitrile (345 mg, 0.766 mmol) and mCPBA (472 mg, 70%, 1.915 mmol) in DCM (10 ml) was stirred at room temperature overnight. The mixture was diluted with water and extracted 2 times with DCM. The combined extracts were washed with 15% Na2SO3 solution, saturated NaHCO3 solution, dried (Na2SO4) and evaporated. The remaining colorless solid (370 mg) was used in the next reaction step without further purification. MS (EI): 482.0 (M+H)+.

Provenance & Evidence