HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-1-cyclopropanecarbonitrile hydrochloride → (1R,2R,4R)-4-(2-Chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-1-cyclopropanecarbonitrile hydrochloride | HCID 14586363 | — |
| Reactant | (1r,2r,4s)-4-(2-Chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid | HCID 66918681 | — |
| Product | (1R,2R,4R)-4-(2-Chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide | HCID 59619283 | — |
Reaction Steps
The title compound was prepared in analogy to example 117 step 7 using (1R,2R,4S)-4-(2-chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (example 186 step 6) and 1-amino-cyclopropyl cyanic hydrochloride. Yellow foam (85%). MS (EI): 504.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893099B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-46e6f722361c4b68be2fd79076270d46 |
| Source note | uspto-grants-2011_02 |