1-Amino-1-cyclopropanecarbonitrile hydrochloride → HCID 59619267, compound

HRID 1367572Notes

Reaction equation

HRID 1367572 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[S:9]([C@@H:12]1[CH2:16][C@@H:15]([C:17]([OH:19])=O)[C@H:14]([C:20]([N:22]2[CH2:26][CH2:25][C:24]([F:28])([F:27])[CH2:23]2)=[O:21])[CH2:13]1)(=[O:11])=[O:10].[CH2:29]1[C:31]([NH2:34])([C:32]#[N:33])[CH2:30]1.Cl>>[C:32]([C:31]1([NH:34][C:17]([C@@H:15]2[CH2:16][C@@H:12]([S:9]([C:3]3[CH:4]=[CH:5][C:6]([Br:8])=[CH:7][C:2]=3[Cl:1])(=[O:10])=[O:11])[CH2:13][C@H:14]2[C:20]([N:22]2[CH2:26][CH2:25][C:24]([F:27])([F:28])[CH2:23]2)=[O:21])=[O:19])[CH2:29][CH2:30]1)#[N:33]

Participants

3

Reactant 2

HCID 145863631-Amino-1-cyclopropanecarbonitrile hydrochlorideHCID 66918920HCID 66918920, compound

Product 1

HCID 59619267HCID 59619267, compound

Procedure

The title compound was prepared in analogy to example 117 step 7 using (1R,2R,4S)-4-(2-chloro-4-bromo-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (example 187 step 3) and 1-amino-cyclopropyl cyanic hydrochloride. Light yellow foam (93%). MS (EI): 566.0 (M+H)+.

Sources & evidence

ORD record
ord-da7dbbbf5ebf4c6b92bf9867d539cd48
Source dataset
uspto-grants-2011_02
Patent number
US07893099B2

Reaction notes

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