Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2,2-Trifluoroethanol → (1R,2R,4R)-4-[2-Chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| 반응물 | (1R,2R,4R)-4-(2-Chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide | HCID 59619283 | — |
| 생성물 | (1R,2R,4R)-4-[2-Chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide | HCID 59619340 | — |
반응 단계
The title compound was prepared in analogy to example 134 using (1R,2R,4R)-4-(2-chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (example 186 step 7) and 2,2,2-trifluoroethanol. White solid (98%). MS (EI): 582.1 (M−H)−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07893099B2 |
| 출처 데이터셋 | uspto-grants-2011_02 |
| ORD ID | ord-6dbb6660671b4c53b123669164dfa6c4 |
| 출처 메모 | uspto-grants-2011_02 |