HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopropylpiperazine → (1R,2R,4R)-4-[2-Chloro-4-(4-cyclopropyl-piperazin-1-yl)-benzenesulfonyl]-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopropylpiperazine | HCID 4742004 | — |
| Reactant | (1R,2R,4R)-4-(2-Chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide | HCID 59619283 | — |
| Product | (1R,2R,4R)-4-[2-Chloro-4-(4-cyclopropyl-piperazin-1-yl)-benzenesulfonyl]-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide | HCID 59619454 | — |
Reaction Steps
The title compound was prepared in analogy to example 127 using (1R,2R,4R)-4-(2-chloro-4-fluoro-benzenesulfonyl)-2-(3,3-difluoro-pyrrolidine-1-carbonyl)-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (example 186 step 7) and N-cyclopropylpiperazine bis hydrobromic salt (CAS # 159974-58-0). White solid (73%). MS (EI): 610.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893099B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-05a21e96df5a4e2eb3540ee02df59bd8 |
| Source note | uspto-grants-2011_02 |