1-(2,2,2-Trifluoroethyl)piperazine → HCID 59619301, compound

Participants

Role	Name	HCID	Charge
Reactant	1-(2,2,2-Trifluoroethyl)piperazine	HCID 9533921	—
Reactant	HCID 59619432	HCID 59619432	—
Reactant	(1S,2S,4S)-4-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-2-methoxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide	HCID 59619475	—
Product	HCID 59619301	HCID 59619301	—

Reaction Steps

The title compound was prepared in analogy to example 176 using 1-(2,2,2-trifluoro-ethyl)-piperazine instead of morpholine and (1R,2R,4R) and (1S,2S,4S)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-2-cyclopentyloxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide (example 195) instead of (1R,2R,4R) and (1S,2S,4S)-4-(4-bromo-2-trifluoromethyl-benzenesulfonyl)-2-methoxy-cyclopentanecarboxylic acid (1-cyano-cyclopropyl)-amide. White solid. MS (EI): 635.2 (M−H)−.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07893099B2
Source dataset	uspto-grants-2011_02
ORD ID	ord-f84e8ebe752146c6a3e59bd4b6028297
Source note	uspto-grants-2011_02