Methanesulfonyl chloride → HCID 58938503, compound

Participants

Reaction Steps

A solution of 14 (123 mg, 0.333 mmol) and MsCl (260 μL, 3.33 mmol) in pyridine (20 mL) was heated to ˜70° C. under N2 for 2 days. The mixture was concentrated in vacuo, and the residue was dissolved in CHCl3, washed with 10% citric acid, dried and concentrated in vacuo. The crude product was purified by flash chromatography eluting with EtOAc/DCM (5-20%) to give pure 15 as a white solid (125 mg, 84%). MS (APCI): m/z 448 (100%, [M+H]+).

Provenance & Evidence