反应详情

In a 50 mL round-bottom flask a mixture of compound 27 (0.67 g, 0028 mol), 3-hydroxy-2-methoxy-benzaldehyde (9, 0.003 mol 0.45 g) and NaOAc (0.233 g, 0.002 mol) in AcOH was heated under reflux for 10 hours. After cooling the precipitate formed was filtered off, washed with water, dried and recrystallized from acetic acid to yield 28 (0.56 g, 55%). M. Wt. 370. LCMS [M+H]+=371.

1. temperaturewas heated
2. temperatureunder reflux for 10 hours
3. temperatureAfter cooling the precipitate
4. customformed
5. filtrationwas filtered off
6. washwashed with water
7. customdried
8. customrecrystallized from acetic acid