Cyclopropylamine → 3-Benzyloxy-1-cyclopropyl-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid

Participants

Reaction Steps

To a suspension of 3-(benzyloxy)-6-methyl-4-oxo-4H-pyran-2-carboxylic acid (2.0 g, 7.685 mmol) in H2O (10 ml) in a reaction tube with a stirrer, was added cyclopropylamine (2.13 ml, 30.74 mmol). A clear light yellow solution was formed. The reaction mixture was heated for ca. 19 h in a sealed tube. The reaction mixture then worked up as described in Procedure II. Thus, the title compound (2.14 g, 93%) was obtained as an off white solid.

Provenance & Evidence