Trifluoroacetic acid → HCID 54012489, compound

Participants

Reaction Steps

In a nitrogen atmosphere, 193 mg (0.5 mmol) of the N-(4-nitrophenoxycarbonyl)phenylalanine t-butyl ester and 5 mL of trifluoroacetic acid were introduced into a round-bottom flask having a capacity of 10 mL. The contents were stirred at room temperature for 1 hour. This reaction mixture was concentrated under reduced pressure with a vacuum pump and then analyzed by NMR spectroscopy using dioxane as an internal reference. As a result, it was found that N-(4-nitrophenoxycarbonyl)phenylalanine had been obtained in a yield of 96%. Furthermore, this reaction mixture was subjected to column isolation to obtain N-(4-nitrophenoxycarbonyl)phenylalanine in an amount of 160 mg (isolation yield, 97%).

Provenance & Evidence