Phosgene → HCID 11561933, compound

HRID 1367704Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[NH:11][C:10]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26][CH2:27][CH3:28])=[N:9]2)=[CH:4][CH:3]=1.[C:29](Cl)([Cl:31])=[O:30]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:29]([Cl:31])=[O:30])[C:10]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26][CH2:27][CH3:28])=[N:9]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6371Phosgene

HCID 66924725HCID 66924725, compound

Product 1

HCID 11561933HCID 11561933, compound

Procedure

(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride was prepared from 4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-phenyl)-4,5-dihydro-imidazole (example 1) and phosgene in an analogous manner as described in example 6.

Sources & evidence

ORD record: ord-260150a6400c43a7bced6341c1a3804e
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07893278B2

Reaction notes

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