HCID 11561933, compound → HCID 11534743, compound

HRID 1367707Notes

Reaction equation

HRID 1367707 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20](Cl)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH2:30][CH3:31])=[N:9]2)=[CH:4][CH:3]=1.Cl.[N:33]1([C:39](=[O:47])[CH2:40][N:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[N:11]([C:20]([N:44]3[CH2:43][CH2:42][N:41]([CH2:40][C:39]([N:33]4[CH2:34][CH2:35][O:36][CH2:37][CH2:38]4)=[O:47])[CH2:46][CH2:45]3)=[O:21])[C:10]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH2:30][CH3:31])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 11561933HCID 11561933, compoundHCID 46743096HCID 46743096, compound

Product 1

HCID 11534743HCID 11534743, compound

Procedure

2-{4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone was prepared from (4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 7) and 1-morpholin-4-yl-2-piperazin-1-yl-ethanone hydrochloride (Oakwood Chemicals) in an analogous manner as described in example 8. HR-MS (ES, m/z) calculated for C34H38N5O4Cl2 [(M+H)+] 650.2296, observed 650.2299.

Sources & evidence

ORD record
ord-ad35cadce95a4285b79fb8c877897d75
Source dataset
uspto-grants-2011_02
Patent number
US07893278B2

Reaction notes

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