HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-Methanesulfonylethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(2-(methylsulfonyl)ethyl)piperazine-1-carboxylate | HCID 66649624 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(2-Methanesulfonylethyl)piperazine dihydrochloride | HCID 17749885 | 99.1% |
Reaction Steps
Hydrochloric acid (42 mL, 168 mmol, 4 M in 1,4-dioxane) was added to a cooled solution of 1-tert-butyloxycarbonyl-4-(2-methanesulfonylethyl)piperazine (2.29 g, 7.8 mmol) in 1,4-dioxane (42 mL). The mixture was stirred at room temperature overnight then concentrated to give 1-(2-methanesulfonylethyl)piperazine bishydrochloride as a white solid (2.05 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893278B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-c908f4ae8d3b4908948f7fdb8e42de56 |
| Source note | uspto-grants-2011_02 |