HCID 11635901, compound → HCID 11542055, compound

HRID 1367711Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11](C(Cl)=O)[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:34])[CH3:33])=[N:9]2)=[CH:4][CH:3]=1.ClC1C=CC([C@H]2[C@@H](C3C=CC(Cl)=CC=3)N([C:54]([N:56]3[CH2:61][CH2:60][N:59]([CH2:62][CH2:63][S:64]([CH3:67])(=[O:66])=[O:65])[CH2:58][CH2:57]3)=[O:55])C(C3C=CC=CC=3OCC)=N2)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[N:11]([C:54]([N:56]3[CH2:57][CH2:58][N:59]([CH2:62][CH2:63][S:64]([CH3:67])(=[O:65])=[O:66])[CH2:60][CH2:61]3)=[O:55])[C:10]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH:32]([CH3:34])[CH3:33])=[N:9]2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 11635901HCID 11635901, compound

HCID 60057215HCID 60057215, compound

Product 1

HCID 11542055HCID 11542055, compound

Procedure

[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone was prepared from (4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 6) and 1-(2-methanesulfonylethyl)-piperazine (example 11) in an analogous manner as described in example 8. LR-MS: 673.3 [(M+H)+].

Sources & evidence

ORD record: ord-af390b5b76a64d7484465cf8664bf362
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07893278B2

Reaction notes

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